2592638-14-5

2592638-14-5 structure

Name: CBP/p300-IN-19 hydrochloride
Chemical Name: CBP/p300-IN-19 hydrochloride
CAS Number: 2592638-14-5
Molecular Formula: C₃₀H₂₈ClN₃O₃
Molecular Weight: 514.01
Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
Create Date: 2022-07-11 18:03:59
Modify Date: 2024-01-12 23:02:44
CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity[1].

Name	CBP/p300-IN-19 hydrochloride

Description	CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Target	p300:1.4 μM (IC50) PCAF:2.2 μM (IC50) CBP:>100 μM (IC50) Myst3:>100 μM (IC50)
In Vitro	CBP/p300-IN-19 hydrochloride (compound 29) shows antiproliferative activity with EC50s of 5.3, 8.5, 6.2, 4.4, 1.2, 4.3, 3.6, 8.7, 6.4 µM for MCF-7, MDA-MB231, LNCaP, PC-3, PANC-1, MDA-PANC-28, Molm-13, MV4;11, RPMI-8226 cells, respectively[1]. CBP/p300-IN-19 hydrochloride (0, 5, 10 µM; 12 h) dose-dependenly inhibits the acetylation of H3K18, H3K9 and K27[1]. Western Blot Analysis[1] Cell Line: Kasumi-1 leukemia cells Concentration: 0, 5, 10 µM Incubation Time: 12 h Result: Dose-dependently inhibited the acetylation of H3K18, H3K9 and K27.
References	[1]. Nie S, et al. Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur J Med Chem. 2022 Jul 5;237:114407.

Molecular Formula	C₃₀H₂₈ClN₃O₃
Molecular Weight	514.01