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2411969-39-4

2411969-39-4 structure
2411969-39-4 structure
  • Name: ARUK3001185
  • Chemical Name: ARUK3001185
  • CAS Number: 2411969-39-4
  • Molecular Formula: C9H4Cl2F3N3
  • Molecular Weight: 282.05
  • Catalog: Signaling Pathways Stem Cell/Wnt Wnt
  • Create Date: 2022-07-01 06:45:52
  • Modify Date: 2024-01-10 19:05:26
  • ARUK3001185 (Compound 8l) is a potent, selective, orally active and brain-penetrant inhibitor of Notum activity with an IC50 of 6.7 nM[1].

Name ARUK3001185
Description ARUK3001185 (Compound 8l) is a potent, selective, orally active and brain-penetrant inhibitor of Notum activity with an IC50 of 6.7 nM[1].
Related Catalog
Target

IC50: 6.7 nM (Notum)[1]

References

[1]. Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65(10):7212-7230.

Molecular Formula C9H4Cl2F3N3
Molecular Weight 282.05
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