2417012-26-9
2417012-26-9 structure
- Name: WDR5 inhibitor 41
- Chemical Name: WDR5 inhibitor 41
- CAS Number: 2417012-26-9
- Molecular Formula: C29H29F3N6O
- Molecular Weight: 534.587
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2022-07-06 12:36:36
- Modify Date: 2024-01-03 15:56:02
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WDR5 inhibitor 41 is a potent, selective and orally bioavailable WDR5 WIN-site inhibitor with TR-FRET Ki value of <0.02 nM, inhibits cell proliferation of MV4:11 and MOLM-13 with IC50 of 13 and 27 nM, respectively.WDR5 inhibitor 41 is well tolerated in mice by both iv and po dosing and showed no clinical sign of abnormalities suggesting an enhanced safetyprofile for the series.
| Name | WDR5 inhibitor 41 |
|---|
| Description | WDR5 inhibitor 41 is a potent, selective and orally bioavailable WDR5 WIN-site inhibitor with TR-FRET Ki value of <0.02 nM, inhibits cell proliferation of MV4:11 and MOLM-13 with IC50 of 13 and 27 nM, respectively.WDR5 inhibitor 41 is well tolerated in mice by both iv and po dosing and showed no clinical sign of abnormalities suggesting an enhanced safetyprofile for the series. |
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| References | 1. Kevin B. Teuscher, et al. J Med Chem. 2022. DOI: 10.1021/acs.jmedchem.2c00195 |
| Molecular Formula | C29H29F3N6O |
|---|---|
| Molecular Weight | 534.587 |