1636894-46-6
1636894-46-6 structure
- Name: KA2507
- Chemical Name: KA2507
- CAS Number: 1636894-46-6
- Molecular Formula: C16H14N6O2
- Molecular Weight: 322.328
- Create Date: 2022-07-29 13:30:30
- Modify Date: 2025-08-25 19:00:18
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KA2507 (KA-2507, KA 2507) is a potent and selective inhibitor of HDAC6 with IC50 of 2.5 nM, >300-fold selectivity over other HDACs.KA2507 demonstrated cellular potency (IC50=150 nM) in a cellular assay measuring induction of acetylated α-tubulin, a marker of HDAC6 inhibition.KA2507 displays antiproliferative effects against a set of 93 human cancer cells with IC50 of 2-30 uM.KA2507 inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model.
| Name | KA2507 |
|---|
| Description | KA2507 (KA-2507, KA 2507) is a potent and selective inhibitor of HDAC6 with IC50 of 2.5 nM, >300-fold selectivity over other HDACs.KA2507 demonstrated cellular potency (IC50=150 nM) in a cellular assay measuring induction of acetylated α-tubulin, a marker of HDAC6 inhibition.KA2507 displays antiproliferative effects against a set of 93 human cancer cells with IC50 of 2-30 uM.KA2507 inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model. |
|---|---|
| References | 1. Apostolia M Tsimberidou, et al. Clin Cancer Res. 2021 Jul 1;27(13):3584-3594. |
| Molecular Formula | C16H14N6O2 |
|---|---|
| Molecular Weight | 322.328 |