Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2411874-83-2

2411874-83-2 structure

2411874-83-2 structure

Name: LDC0496
Chemical Name: LDC0496
CAS Number: 2411874-83-2
Molecular Formula: C₃₂H₃₅N₅O₃
Molecular Weight: 537.65
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-07-02 11:55:20
Modify Date: 2025-08-26 19:20:50
LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].

Name	LDC0496

Description	LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 0.152 ± 0.011 μM in Ba/F3 (EGFR-insNPH), 0.162 ± 0.010 μM in Ba/F3 (Her2-insYVMA), 2.660 ± 0.129 in A431[1]
References	[1]. Lategahn J, et al. Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J Med Chem. 2022;65(9):6643-6655.

Molecular Formula	C₃₂H₃₅N₅O₃
Molecular Weight	537.65

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.