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2411874-83-2

2411874-83-2 structure

2411874-83-2 structure

Name: LDC0496
Chemical Name: LDC0496
CAS Number: 2411874-83-2
Molecular Formula: C₃₂H₃₅N₅O₃
Molecular Weight: 537.65
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-07-02 11:55:20
Modify Date: 2024-01-22 11:24:18
LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].

Name	LDC0496

Description	LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 0.152 ± 0.011 μM in Ba/F3 (EGFR-insNPH), 0.162 ± 0.010 μM in Ba/F3 (Her2-insYVMA), 2.660 ± 0.129 in A431[1]
References	[1]. Lategahn J, et al. Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J Med Chem. 2022;65(9):6643-6655.

Molecular Formula	C₃₂H₃₅N₅O₃
Molecular Weight	537.65

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