2744683-81-4

2744683-81-4 structure
2744683-81-4 structure
  • Name: Famotidine-13C,d3
  • Chemical Name: Famotidine-13C,d3
  • CAS Number: 2744683-81-4
  • Molecular Formula: C713CH12D3N7O2S3
  • Molecular Weight: 341.46
  • Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
  • Create Date: 2022-07-12 13:50:15
  • Modify Date: 2024-01-09 19:05:30
  • Famotidine-13C,d3 is the 13C- and deuterium labeled. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Name Famotidine-13C,d3
Description Famotidine-13C,d3 is the 13C- and deuterium labeled. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[63].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. Inan, A., et al., Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo), 2009. 64(6): p. 567-70.

[3]. Miyata, K., et al., Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol, 1991. 55(2): p. 211-22.

Molecular Formula C713CH12D3N7O2S3
Molecular Weight 341.46