2374723-26-7
2374723-26-7 structure
- Name: As-358 hydrochloride
- Chemical Name: As-358 hydrochloride
- CAS Number: 2374723-26-7
- Molecular Formula: C18H32ClNO2
- Molecular Weight: 329.91
- Catalog: Signaling Pathways Anti-infection Filovirus
- Create Date: 2022-06-11 12:41:16
- Modify Date: 2024-01-09 14:25:41
-
As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].
| Name | As-358 hydrochloride |
|---|
| Description | As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus)[1] |
| In Vitro | As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1]. Cell Proliferation Assay Cell Line: Vero (infected with EBOV and MARV)[1] Concentration: 0-500 μM Incubation Time: 10 days Result: Exhibits inhibitory activities against EBOV and MARV, with IC50s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively. |
| In Vivo | As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1]. Animal Model: ICR mice[1] Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg Administration: IG; single (observed for 7 days) Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg. |
| References |
| Molecular Formula | C18H32ClNO2 |
|---|---|
| Molecular Weight | 329.91 |