2276711-87-4

2276711-87-4 structure

Name: Xanthine oxidase-IN-5
Chemical Name: Xanthine oxidase-IN-5
CAS Number: 2276711-87-4
Molecular Formula: C₁₈H₁₆FN₃O₃
Molecular Weight: 341.34
Catalog: Signaling Pathways Metabolic Enzyme/Protease Xanthine Oxidase
Create Date: 2022-05-21 15:06:55
Modify Date: 2024-01-13 23:13:40
Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC50 value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable drug-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model[1].

Name	Xanthine oxidase-IN-5

Description	Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC50 value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable drug-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
Target	IC50: 0.70 μM (XO)[1]
In Vivo	Xanthine oxidase-IN-5 (compound 9m) shows potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate[1]. Animal Model: Potassium oxonate-induced hyperuricemic rat model[1] Dosage: 20 mg/kg Administration: PO; single (measured serum uric acid after 0.5 - 8 hours) Result: Showed potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate.
References	[1]. Zhang TJ, Zhang Y, Zhang ZH, et al. Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors. Bioorg Med Chem Lett. 2022;60:128582.

Molecular Formula	C₁₈H₁₆FN₃O₃
Molecular Weight	341.34