2755772-63-3
2755772-63-3 structure
- Name: Immunoproteasome inhibitor 1
- Chemical Name: Immunoproteasome inhibitor 1
- CAS Number: 2755772-63-3
- Molecular Formula: C20H26N2O4
- Molecular Weight: 358.43
- Create Date: 2022-06-29 15:23:29
- Modify Date: 2024-01-06 11:48:59
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Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (Kis of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the treatment of certain neoplastic diseases[1].
| Name | Immunoproteasome inhibitor 1 |
|---|
| Description | Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (Kis of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the treatment of certain neoplastic diseases[1]. |
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| Related Catalog | |
| Target |
β5c submit:1.18 μM (Ki) β1i submit:0.27 μM (Ki) β2i submit:20 μM (Ki) β5i submit:1.91 μM (Ki) |
| In Vitro | Immunoproteasome inhibitor 1 (compound 9) (0-25 μM; 0-600 seconds; in Human 20S immunoproteasome and human 20S proteasome) has high binding affinity for the β1i subunit (0.27 µM) of immunoproteasome and proteasome, coupling with good inhibitory properties towards β5i and β5c subunits. And the results of against the β5i subunit shows that the inhibition is reversible, time-independent[1]. |
| References |
| Molecular Formula | C20H26N2O4 |
|---|---|
| Molecular Weight | 358.43 |