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2683008-37-7

2683008-37-7 structure
2683008-37-7 structure
  • Name: OARV-771
  • Chemical Name: OARV-771
  • CAS Number: 2683008-37-7
  • Molecular Formula: C49H59ClN8O8S2
  • Molecular Weight: 987.62
  • Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
  • Create Date: 2022-04-13 19:55:56
  • Modify Date: 2024-01-09 20:38:58
  • OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively[1].
Name OARV-771
Description OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively[1].
Related Catalog
Target

BRD4:6 nM (DC50)

BRD2:1 nM (DC50)

BRD3:4 nM (DC50)

VHL

In Vitro OARV-771 shows antiproliferative effect with an EC50 value of 4 nM in MV4;11[1].
References

[1]. Klein VG, et al. Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. J Med Chem. 2021;64(24):18082-18101.
Molecular Formula C49H59ClN8O8S2
Molecular Weight 987.62

Chemsrc provides CAS#:2683008-37-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2683008-37-7 | Chemsrc address: https://www.chemsrc.com/en/baike/1704928.html

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