2703054-47-9
2703054-47-9 structure
- Name: Adenosine receptor antagonist 2
- Chemical Name: Adenosine receptor antagonist 2
- CAS Number: 2703054-47-9
- Molecular Formula: C23H21FN8O
- Molecular Weight: 444.46
- Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
- Create Date: 2022-05-23 15:50:22
- Modify Date: 2024-01-12 18:28:22
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Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity[1].
| Name | Adenosine receptor antagonist 2 |
|---|
| Description | Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
A2a adenosine receptor:1 nM (IC50) A2b adenosine receptor:3 nM (IC50) |
| In Vivo | Adenosine receptor antagonist 2 (compound L-1; po; 10, 30, 100 mg/kg; twice a day for 22 days) inhibits tumor growth in female C57BL / 6mice mice with MC38(#22)-hpd-L1 cells[1]. Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min·kg and an AUC of 2252 h·ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a Cmax of 8730 ng/mL in adult male ICR mice (weight 25-40g)[1]. |
| References |
| Molecular Formula | C23H21FN8O |
|---|---|
| Molecular Weight | 444.46 |