24909-18-0

24909-18-0 structure

Name: 2,5-Cyclohexadiene-1,4-dione,2,5-bis(4-ethylphenyl)-3,6-dihydroxy-
Chemical Name: 2,5-bis(4-ethylphenyl)-3,6-dihydroxycyclohexa-2,5-diene-1,4-dione
CAS Number: 24909-18-0
Molecular Formula: C₂₂H₂₀O₄
Molecular Weight: 348.39200
Create Date: 2017-05-10 06:11:17
Modify Date: 2025-08-25 16:30:56
NSC114126 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC114126 has strong antiproliferative activities. NSC114126 has the potential for the research of cancer diseases[1].

Name	2,5-bis(4-ethylphenyl)-3,6-dihydroxycyclohexa-2,5-diene-1,4-dione
Synonyms	2,5-Bis-(p-ethylphenyl)-3,6-dihydroxy-p-benzochinon p-Benzoquinone,2,5-bis(p-ethylphenyl)-3,6-dihydroxy

Description	NSC114126 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC114126 has strong antiproliferative activities. NSC114126 has the potential for the research of cancer diseases[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Jiwacharoenchai N, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022;58:128524.

28293-35-8

24909-18-0

Literature: Zee-Cheng,K.-Y.; Cheng,C.C. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 264 - 268

615-93-0

24909-18-0

Literature: Zee-Cheng,K.-Y.; Cheng,C.C. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 264 - 268

589-16-2

24909-18-0

Literature: Zee-Cheng,K.-Y.; Cheng,C.C. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 264 - 268

Precursor 3
28293-35-8 615-93-0 589-16-2
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