1310361-52-4

1310361-52-4 structure

Name: a-FABP-IN-1
Chemical Name: HM 50316
CAS Number: 1310361-52-4
Molecular Formula: C₂₉H₂₃ClN₂O₃S
Molecular Weight: 515.02
Catalog: Signaling Pathways Metabolic Enzyme/Protease FABP
Create Date: 2022-03-26 11:28:50
Modify Date: 2024-04-05 19:27:08
a-FABP-IN-1 (Compound 5g) is a potent and selective human adipocyte fatty acid-binding protein (a-FABP) inhibitor with a Ki below 1.0 nM. a-FABP-IN-1 inhibits the pro-inflammatory cytokine production[1].

Name	HM 50316
Synonyms	compound 5g [PMID: 21481589] 2-({2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl]-3-biphenylyl}oxy)-2-methylpropanoic acid Propanoic acid, 2-[[2'-[1-(4-chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methyl- 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid

Description	a-FABP-IN-1 (Compound 5g) is a potent and selective human adipocyte fatty acid-binding protein (a-FABP) inhibitor with a Ki below 1.0 nM. a-FABP-IN-1 inhibits the pro-inflammatory cytokine production[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> FABP
Target	Ki: <1.0 nM (a-FABP)[1]
References	[1]. Liu X, et al. New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg Med Chem Lett. 2011 May 15;21(10):2949-52.