1048660-43-0

1048660-43-0 structure

Name: ROC-0929
Chemical Name: ROC-0929
CAS Number: 1048660-43-0
Molecular Formula: C₃₀H₃₁N₃O₆S
Molecular Weight: 561.65
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2022-03-03 20:42:33
Modify Date: 2024-01-29 10:42:32
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for the treatment of inflammation related diseases[1].

Name	ROC-0929

Description	ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for the treatment of inflammation related diseases[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology
Target	80 nM (hGX)[1]
References	[1]. Oslund RC, et al. Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J Med Chem. 2008;51(15):4708-4714. [2]. Hallstrand TS, et al. Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils. J Allergy Clin Immunol. 2016;137(1):268-277.e8.

Molecular Formula	C₃₀H₃₁N₃O₆S
Molecular Weight	561.65