342795-11-3

342795-11-3 structure

Name: Namoline
Chemical Name: Namoline
CAS Number: 342795-11-3
Molecular Formula: C₁₀H₃ClF₃NO₄
Molecular Weight: 293.58
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2022-02-21 13:41:51
Modify Date: 2024-01-06 15:11:23
Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research[1].

Name	Namoline

Description	Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
In Vitro	Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells[1]. Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells[1]. Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions[1].
In Vivo	Namoline (0.02 mg;ip; daily) severely blunts xenograft tumor growth in nude mice with LNCaP cells[1].
References	[1]. Dominica Willmann, et al. Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer. 2012 Dec 1;131(11):2704-9.

Molecular Formula	C₁₀H₃ClF₃NO₄
Molecular Weight	293.58