2095064-05-2

2095064-05-2 structure

Name: Posenacaftor
Chemical Name: Posenacaftor
CAS Number: 2095064-05-2
Molecular Formula: C₂₇H₂₇NO₅
Molecular Weight: 445.51
Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
Create Date: 2022-02-20 18:34:29
Modify Date: 2024-01-28 17:19:43
Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF)[1].

Name	Posenacaftor

Description	Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF)[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Inflammation/Immunology
In Vitro	Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR)[1]. CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells. Mutations in the CFTR gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells[1]. Posenacaftor is a CFTR corrector, correctors are designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways[2].
References	[1]. Benjamin Kopp, et al. Compositions et procédés pour améliorer la fonction cftr dans des cellules affectées par la fibrose kystique. Patent WO2019156946. [2]. Posenacaftor (PTI-801)

Molecular Formula	C₂₇H₂₇NO₅
Molecular Weight	445.51