458151-34-3

458151-34-3 structure

Name: Thalidomide-benzo
Chemical Name: Thalidomide-benzo
CAS Number: 458151-34-3
Molecular Formula: C₁₇H₁₂N₂O₄
Molecular Weight: 308.29
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2021-12-20 11:58:57
Modify Date: 2025-10-08 12:16:05
Thalidomide-benzo hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-benzo can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	Thalidomide-benzo

Description	Thalidomide-benzo hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-benzo can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.