2396639-11-3
2396639-11-3 structure
- Name: RB-3
- Chemical Name: RB-3
- CAS Number: 2396639-11-3
- Molecular Formula: C24H20ClN3O2
- Molecular Weight: 417.89
- Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
- Create Date: 2021-12-19 18:09:39
- Modify Date: 2025-09-01 11:29:34
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RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1].
| Name | RB-3 |
|---|
| Description | RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd: 2.8 μM (RING1B-BMI1f)[1]. |
| In Vitro | RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1]. RB-3 inhibits H2A ubiquitination with an IC50 of 1.6 μM[1]. RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1]. RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1]. Western Blot Analysis[1] Cell Line: TEX cells. Concentration: 6, 12, 25 μM. Incubation Time: 8d. Result: Dose-dependently increased C/EBPα-p42 protein levels. |
| References |
| Molecular Formula | C24H20ClN3O2 |
|---|---|
| Molecular Weight | 417.89 |