497146-96-0

497146-96-0 structure

Name: Pomalidomide-7-NH2
Chemical Name: Pomalidomide-7-NH2
CAS Number: 497146-96-0
Molecular Formula: C₁₃H₁₂N₄O₄
Molecular Weight: 288.26
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2021-12-23 13:40:06
Modify Date: 2024-01-09 18:20:57
Pomalidomide-7-NH2 is the Pomalidomide-based cereblon ligand used in the recruitment of CRBN protein. Pomalidomide-7-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	Pomalidomide-7-NH2

Description	Pomalidomide-7-NH2 is the Pomalidomide-based cereblon ligand used in the recruitment of CRBN protein. Pomalidomide-7-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.