1072874-90-8
1072874-90-8 structure
- Name: Miravirsen
- Chemical Name: Miravirsen
- CAS Number: 1072874-90-8
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Epigenetics MicroRNA
- Create Date: 2021-12-27 11:59:41
- Modify Date: 2024-01-02 14:14:44
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Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122. Miravirsen (SPC-3649) is used in the study for HCV infections[1].
| Name | Miravirsen |
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| Description | Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122. Miravirsen (SPC-3649) is used in the study for HCV infections[1]. |
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| Related Catalog | |
| In Vitro | Miravirsen is thought to work mainly by hybridizing to mature miR-122 and blocking its interaction with HCV RNA, its target sequence is also present in pri- and pre-miR-122[1]. Miravirsen binds to the stem-loop structure of pri- and pre-miR-122 with nanomolar affinity, and inhibits both Dicer- and Drosha-mediated processing of miR-122 precursors[1]. |
| References |
| No Any Chemical & Physical Properties |