2211082-53-8

2211082-53-8 structure

Name: Gunagratinib
Chemical Name: Gunagratinib
CAS Number: 2211082-53-8
Molecular Formula: C₂₂H₂₅N₅O₄
Molecular Weight: 423.47
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2021-12-20 09:14:53
Modify Date: 2025-08-25 19:02:19
Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer[1].

Name	Gunagratinib

Description	Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR
In Vitro	Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding[1].
References	[1]. Guo Ye, et al. Phase I result of ICP-192 (gunagratinib), a highly selective irreversible FGFR inhibitor, in patients with advanced solid tumors harboring FGFR pathway alterations. Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021) 4092-4092.

Molecular Formula	C₂₂H₂₅N₅O₄
Molecular Weight	423.47