2230282-02-5

2230282-02-5 structure

Name: Lorpucitinib
Chemical Name: 2-{1-[trans-4-(Cyanomethyl)cyclohexyl]-1,5-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}-N-(2-hydroxy-2-methylpropyl)acetamide
CAS Number: 2230282-02-5
Molecular Formula: C₂₂H₂₈N₆O₂
Molecular Weight: 408.50
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2021-12-20 15:01:46
Modify Date: 2024-01-09 17:25:09
Lorpucitinib is a Gut-Restricted JAK Inhibitor for the research of Inflammatory Bowel Disease[1].

Name	2-{1-[trans-4-(Cyanomethyl)cyclohexyl]-1,5-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}-N-(2-hydroxy-2-methylpropyl)acetamide
Synonyms	Imidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-acetamide, 1-[trans-4-(cyanomethyl)cyclohexyl]-1,5-dihydro-N-(2-hydroxy-2-methylpropyl)- 2-{1-[trans-4-(Cyanomethyl)cyclohexyl]-1,5-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}-N-(2-hydroxy-2-methylpropyl)acetamide

Description	Lorpucitinib is a Gut-Restricted JAK Inhibitor for the research of Inflammatory Bowel Disease[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
References	[1]. Leonard KA, Madge LA, Krawczuk PJ, Wang A, Kreutter KD, Bacani GM, Chai W, Smith RC, Tichenor MS, Harris MC, Malaviya R, Seierstad M, Johnson ME, Venable JD, Kim S, Hirst GC, Mathur AS, Rao TS, Edwards JP, Rizzolio MC, Koudriakova T. Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2020 Mar 26;63(6):2915-2929.