1380539-06-9

1380539-06-9 structure

Name: Fosciclopirox
Chemical Name: [(6-Cyclohexyl-4-methyl-2-oxo-1(2H)-pyridinyl)oxy]methyl dihydrogen phosphate
CAS Number: 1380539-06-9
Molecular Formula: C₁₃H₂₀NO₆P
Molecular Weight: 317.27
Catalog: Research Areas Cancer
Create Date: 2022-01-12 20:26:53
Modify Date: 2024-01-14 12:00:56
Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract[1][2]. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies.

Name	[(6-Cyclohexyl-4-methyl-2-oxo-1(2H)-pyridinyl)oxy]methyl dihydrogen phosphate
Synonyms	2(1H)-Pyridinone, 6-cyclohexyl-4-methyl-1-[(phosphonooxy)methoxy]- [(6-Cyclohexyl-4-methyl-2-oxo-1(2H)-pyridinyl)oxy]methyl dihydrogen phosphate

Description	Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract[1][2]. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies.
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease
References	[1]. Weir SJ, Dandawate P, Standing D, Bhattacharyya S, Ramamoorthy P, Rangarajan P, Wood R, Brinker AE, Woolbright BL, Tanol M, Ham T, McCulloch W, Dalton M, Reed GA, Baltezor MJ, Jensen RA, Taylor JA 3rd, Anant S. Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex. Cell Death Dis. 2021 May 31;12(6):562. [2]. Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159.