1217625-98-3

1217625-98-3 structure
1217625-98-3 structure
  • Name: RPR132595A-d3
  • Chemical Name: RPR132595A-d3
  • CAS Number: 1217625-98-3
  • Molecular Formula: C28H27D3N4O6
  • Molecular Weight: 521.58
  • Catalog: Research Areas Cancer
  • Create Date: 2021-10-25 12:21:10
  • Modify Date: 2024-01-10 01:10:58
  • RPR132595A-d3 is the deuterium labeled RPR132595A. RPR132595A is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine[1][2].

Name RPR132595A-d3
Description RPR132595A-d3 is the deuterium labeled RPR132595A. RPR132595A is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Alvau MD, et al. Enzyme-Based Electrochemical Biosensor for Therapeutic Drug Monitoring of Anticancer Drug Irinotecan.Anal Chem. 2018 May 15;90(10):6012-6019.

Molecular Formula C28H27D3N4O6
Molecular Weight 521.58