309735-05-5

309735-05-5 structure

Name: ABC-1
Chemical Name: ABC-1
CAS Number: 309735-05-5
Molecular Formula: C₁₆H₁₆N₂OS
Molecular Weight: 284.38
Catalog: Research Areas Infection
Create Date: 2021-12-30 12:19:22
Modify Date: 2024-01-14 20:20:48
ABC-1 is a phosphorylated analogue and a potential antiviral agent against Newcastle disease virus (NDV). ABC-1 has potent antiviral activity[1][2].

Name	ABC-1

Description	ABC-1 is a phosphorylated analogue and a potential antiviral agent against Newcastle disease virus (NDV). ABC-1 has potent antiviral activity[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	ABC-1 (175 and 350 μM; 96 hours) potently inhibits Cytopathic effect (CPE) [1]. Cell Cytotoxicity Assay[1] Cell Line: DF-1 cells Concentration: 175 and 350 μM Incubation Time: 96 hours Result: Inhibits Cytopathic effect (CPE).
In Vivo	ABC-1 (2 mg/kg; Oral) reduces colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals[2]. Animal Model: Chickens (NDV treated) [2] Dosage: 2 mg/kg Administration: Oral Result: Reduced colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals.
References	[1]. K A S, et al. Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken. Appl Biochem Biotechnol. 2016;180(2):361-381. [2]. Suresh KA, et al. Phosphorylated abacavir analogue (ABC-1) has ameliorative action against Newcastle disease virus induced pathogenesis in chicken. Biotechnol Appl Biochem. 2019;66(6):977-989.