917953-08-3
917953-08-3 structure
- Name: HXR9
- Chemical Name: HXR9
- CAS Number: 917953-08-3
- Molecular Formula: C119H193N53O20S
- Molecular Weight: 2718.21
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2021-09-09 01:30:47
- Modify Date: 2025-08-25 13:19:40
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HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells[1][2][3].
| Name | HXR9 |
|---|
| Description | HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells[1][2][3]. |
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| Related Catalog | |
| In Vitro | HXR9 (60μM; 4 hours) blocks the interaction between PBX and HOX[1]. HXR9 (60μM; 2 hours) triggers apoptosis in B16 and primary melanoma cells[1]. HXR9 (60μM; 2 hours) causes specific transcriptional changes[1]. HXR9 (B16 cells) shows antiproliferative activity with an IC50 of 20μM[1]. Western Blot Analysis Cell Line: murine B16melanoma cells Concentration: 60 μM Incubation Time: 4 hours Result: Blocked the binding of HOXD9 to PBX. Apoptosis Analysis Cell Line: B16 cells Concentration: 60 μM Incubation Time: 2 hours Result: A significant proportion of cells were in late phases of apoptosis. RT-PCR Cell Line: B16F10cells Concentration: 60 μM Incubation Time: 2 hours Result: Fos, Jun, Dusp1, and Atf1，were allsignificantly up-regulate. |
| In Vivo | HXR9 (10 mg/kg; i.v. via the tail vein; twice weekly) blocks tumor growth[1]. HXR9 (Initial dose of 100 mg/kg (subsequent dosing of 10 mg/kg twice weekly);Intraperitoneal; twice weekly for 18 days) blocks A549 tumour growth in vivo[3]. Animal Model: C57black/6 mice (bearing B16 cells) Dosage: 10 mg/kg Administration: I.v. via the tail vein; twice weekly (~30 days) Result: Tumors showed a significant degree of growth retardation. Animal Model: Athymic nude mice (bearing A549 cells) Dosage: Initial dose of 100 mg/kg (subsequent dosing of 10 mg/kg twice weekly) Administration: Intraperitoneal; twice weekly for 18 days Result: The tumours of HXR9-treated mice were considerably smaller than those of the control groups. |
| References |
[2]. Li Z, et al. PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood. 2013;121(8):1422-1431. |
| Molecular Formula | C119H193N53O20S |
|---|---|
| Molecular Weight | 2718.21 |