1185736-98-4
1185736-98-4 structure
- Name: ELOVL6-IN-1
- Chemical Name: ELOVL6-IN-1
- CAS Number: 1185736-98-4
- Molecular Formula: C27H24F3N3O3
- Molecular Weight: 495.49
- Catalog: Research Areas Metabolic Disease
- Create Date: 2021-09-10 20:09:25
- Modify Date: 2025-08-25 21:13:40
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ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].
| Name | ELOVL6-IN-1 |
|---|
| Description | ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1]. |
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| Related Catalog | |
| Target |
IC50: 0.35 μM (ELOVL6), Ki: 994 nM (ELOVL6)[1] |
| In Vitro | ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1]. |
| In Vivo | ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1]. ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1]. ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1]. Animal Model: C57BL/6J mice Dosage: 10 mg/kg Administration: P.o. Result: Displayed appreciable plasma and liver exposure. Animal Model: C57BL/6J mice Dosage: 10 and 30 mg/kg Administration: P.o. Result: Reduced the elongation index of the liver lipids. Animal Model: C57BL/6J mice Dosage: 100 mg/kg Administration: P.o. Result: Reduced the elongation index of the total fatty acids of the liver. |
| References |
| Molecular Formula | C27H24F3N3O3 |
|---|---|
| Molecular Weight | 495.49 |