2411088-26-9
2411088-26-9 structure
- Name: CC260
- Chemical Name: CC260
- CAS Number: 2411088-26-9
- Molecular Formula: C24H29Cl2N5O2
- Molecular Weight: 490.43
- Catalog: Research Areas Cancer
- Create Date: 2021-09-10 11:28:09
- Modify Date: 2025-08-25 16:35:43
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CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1].
| Name | CC260 |
|---|
| Description | CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 40 nM (PI5P4Kα) and 30 nM (PI5P4Kβ)[1] |
| In Vitro | In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1]. CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosphorylation of acetyl-CoA carboxylase (ACC) in a dose-dependent manner[1]. CC260 treatment reduces the ability of BT474 cells to survive serum starvation, which could be rescued by expressing the PI5P4Kβ refractory mutant[1]. In BT474 cells, CC260 treatment causes an increase in glycolytic ATP production[1]. |
| References |
| Molecular Formula | C24H29Cl2N5O2 |
|---|---|
| Molecular Weight | 490.43 |