Name | BCAT-IN-1 |
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Description | BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC50 of 7.3. BCAT-IN-1 shows 100-fold selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 can be used for the research of metabolic diseases[1]. |
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Related Catalog | |
Target |
pIC50: 7.3 (BCATm)[1] |
In Vitro | BCAT-IN-1 (compound 8b) inhibits BCATm in human cells, with a pIC50 of 7.0[1]. BCAT-IN-1 inhibits mouse BCATm, with pIC50 of 5.9 in the cellular assay[1]. |
In Vivo | BCAT-IN-1 (compound 8b) (30-300 mg/kg; p.o.) increases the level of c BCAAs in an acute mouse model over an extended duration[1]. BCAT-IN-1 (5 mg/kg; p.o.) exhibits oral bioavailability (F=28%) and Cmax (1648 ng/mL) in mice[1]. BCAT-IN-1 (1 mg/kg; i.v.) exhibits half-life (t1/2=9.2 h) and clearance (Cl=4.0 mL/min/kg) in mice[1]. |
References |
Molecular Formula | C25H24BrN5O2S |
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Molecular Weight | 538.46 |