1858291-14-1

1858291-14-1 structure

Name: (3S,4S)-PF-06459988
Chemical Name: (3S,4S)-PF-06459988
CAS Number: 1858291-14-1
Molecular Formula: C₁₉H₂₂ClN₇O₃
Molecular Weight: 431.88
Catalog: Research Areas Cancer
Create Date: 2021-09-11 09:45:42
Modify Date: 2025-09-12 23:16:50
(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling[1].

Name	(3S,4S)-PF-06459988

Description	(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	EGFR[1]
References	[1]. Cheng, H., et al. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. Journal of Medicinal Chemistry, 59(5), 2005–2024.

Molecular Formula	C₁₉H₂₂ClN₇O₃
Molecular Weight	431.88