1923844-48-7
1923844-48-7 structure
- Name: BMS-986242
- Chemical Name: BMS986242
- CAS Number: 1923844-48-7
- Molecular Formula: C24H24ClFN2O
- Molecular Weight: 410.91
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Indoleamine 2,3-Dioxygenase (IDO)
- Create Date: 2021-09-26 03:27:32
- Modify Date: 2025-08-25 20:39:59
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BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer[1].
| Name | BMS986242 |
|---|
| Description | BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
IDO1 |
| In Vitro | BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ∼20 % max inhibition)[1]. |
| In Vivo | BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses[1]. Animal Model: nu/nu Mouse[1] Dosage: 3~30 mg/kg Administration: P.o. Result: Exhibited dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses. |
| References |
| Molecular Formula | C24H24ClFN2O |
|---|---|
| Molecular Weight | 410.91 |