Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate
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5948-75-4

5948-75-4 structure

Name: ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate
Chemical Name: Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-sulfanyl-1,4-dihydropyrimidine-5-carboxylate
CAS Number: 5948-75-4
Molecular Formula: C₁₅H₁₈N₂O₄S
Molecular Weight: 322.38
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2021-09-23 14:59:04
Modify Date: 2024-08-09 17:02:29
gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells[1].

Name	Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-sulfanyl-1,4-dihydropyrimidine-5-carboxylate
Synonyms	Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-, ethyl ester 5-pyrimidinecarboxylic acid, 1,4-dihydro-4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-, ethyl ester 5-pyrimidinecarboxylic acid, 1,6-dihydro-6-(4-hydroxy-3-methoxyphenyl)-2-mercapto-4-methyl-, ethyl ester ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Ethyl 6-(4-hydroxy-3-methoxyphenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate MFCD02331148 Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-sulfanyl-1,4-dihydropyrimidine-5-carboxylate

Description	gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Inflammation/Immunology
Target	HIV-1:2.2 μM (IC50) HIV-1:100.90 μM (CC50)
References	[1]. Senapathi J, et al. Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at "Phe43 cavity" of HIV-1 gp120. Bioorg Med Chem. 2021 Dec 15;52:116526.