265980-25-4

265980-25-4 structure

Name: SCH 202676 hydrobromide
Chemical Name: SCH 202676 (hydrobromide)
CAS Number: 265980-25-4
Molecular Formula: C₁₅H₁₄BrN₃S
Molecular Weight: 348.261
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2021-09-14 14:36:12
Modify Date: 2024-04-03 09:38:01
SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 hydrobromide has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 μM[1][2][3][4].

Name	SCH 202676 (hydrobromide)
Synonyms	N-[(5Z)-2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene]methanamine hydrobromide (1:1) MFCD06671539 (5Z)-N-Methyl-2,3-diphenyl-1,2,4-thiadiazol-5(2H)-imine hydrobromide (1:1) Methanamine, N-[(5Z)-2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene]-, hydrobromide (1:1) SCH 202676 (hydrobromide)

Description	SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 hydrobromide has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 μM[1][2][3][4].
Related Catalog	Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
References	[1]. Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129. [2]. Lewandowicz AM, et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147(4):422-9. [3]. Fawzi A B, et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors[J]. Molecular Pharmacology, 2001, 59(1): 30-37. [4]. Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74(25):3173-80.