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1268674-16-3

1268674-16-3 structure

1268674-16-3 structure

Name: HDAC-IN-55
Chemical Name: 5-(furan-2-yl)-N-(4-(pyridin-4-yl)butyl)isoxazole-3-carboxaMide
CAS Number: 1268674-16-3
Molecular Formula: C₁₇H₁₇N₃O₃
Molecular Weight: 311.34
Create Date: 2021-09-16 17:31:50
Modify Date: 2024-04-06 23:05:15
HDAC-IN-55(8j) is a small molecular compound that can increase the expression of E-cadherin and inhibit the proliferation of cancer cells[1].

Name	5-(furan-2-yl)-N-(4-(pyridin-4-yl)butyl)isoxazole-3-carboxaMide

Description	HDAC-IN-55(8j) is a small molecular compound that can increase the expression of E-cadherin and inhibit the proliferation of cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	HDAC-IN-55(8j) 作用于SW620 细胞系和 H520 细胞系的 EC50 值分别是 4.47 和 1.61 μM[1]。 HDAC-IN-55(8j) (10 μM, 24 h) 可以使 SW620 细胞中的 E-钙粘蛋白表达增加，并抑制 SW620 细胞增殖[1]。
References	[1]. Sydney L Stoops, et al. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol. 2011 May 20;6(5):452-65.

Molecular Formula	C₁₇H₁₇N₃O₃
Molecular Weight	311.34

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