1903763-83-6
1903763-83-6 structure
- Name: Sisunatovir HCl
- Chemical Name: Sisunatovir HCl
- CAS Number: 1903763-83-6
- Molecular Formula: C23H23ClF4N4O
- Molecular Weight: 482.91
- Create Date: 2021-09-10 18:36:41
- Modify Date: 2026-06-30 07:07:17
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Sisunatovir, also known as RV521, is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo.
| Name | Sisunatovir HCl |
|---|
| Description | Sisunatovir, also known as RV521, is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo. |
|---|
| Molecular Formula | C23H23ClF4N4O |
|---|---|
| Molecular Weight | 482.91 |