25849-90-5
25849-90-5 structure
- Name: TRV055
- Chemical Name: TRV055
- CAS Number: 25849-90-5
- Molecular Formula: C42H57N9O9
- Molecular Weight: 831.96
- Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
- Create Date: 2021-07-28 16:39:26
- Modify Date: 2024-01-16 18:49:10
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TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists[1].
| Name | TRV055 |
|---|
| Description | TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists[1]. |
|---|---|
| Related Catalog | |
| In Vitro | TRV055 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1]. |
| References |
| Molecular Formula | C42H57N9O9 |
|---|---|
| Molecular Weight | 831.96 |