Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AST5902
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: AST5902
Price: ￥1.0/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: AST5902
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

2412155-74-7

2412155-74-7 structure

2412155-74-7 structure

Name: AST5902
Chemical Name: AST5902
CAS Number: 2412155-74-7
Molecular Formula: C₂₇H₂₉F₃N₈O₂
Molecular Weight: 554.24
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2021-06-05 06:45:20
Modify Date: 2025-09-12 17:38:47
AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor). AST5902 has antineoplastic activity[1][2].

Name	AST5902

Description	AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor). AST5902 has antineoplastic activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Zhu YT, et al. Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers. Invest New Drugs. 2021 Aug;39(4):1011-1018. [2]. Liu XY, Guo ZT, Chen ZD, Zhang YF, Zhou JL, Jiang Y, Zhao QY, Diao XX, Zhong DF. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta Pharmacol Sin. 2020 Oct;41(10):1366-1376.

Molecular Formula	C₂₇H₂₉F₃N₈O₂
Molecular Weight	554.24

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