179691-97-5

179691-97-5 structure

Name: 2,5-Dihydroxycinnamic Acid phenethyl ester
Chemical Name: 2,5-Dihydroxycinnamic Acid phenethyl ester
CAS Number: 179691-97-5
Molecular Formula: C₁₇H₁₆O₄
Molecular Weight: 284.31
Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
Create Date: 2021-04-30 13:15:39
Modify Date: 2024-01-20 13:25:00
5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research[1].

Name	2,5-Dihydroxycinnamic Acid phenethyl ester
Synonyms	2-Phenylethyl (2E)-3-(2,5-dihydroxyphenyl)acrylate 2-phenylethyl (2E)-3-(2,5-dihydroxyphenyl)prop-2-enoate β-Phenylethyl 2,5-dihydroxycinnamate 2-Propenoic acid, 3-(2,5-dihydroxyphenyl)-, 2-phenylethyl ester, (2E)-

Description	5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	5-LOX:0.33 μM (IC50)
References	[1]. Selka A, et.al. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. Eur J Med Chem. 2019 Oct 1;179:347-357.