1346601-82-8

1346601-82-8 structure

Name: Deferiprone-d3
Chemical Name: Deferiprone-d3
CAS Number: 1346601-82-8
Molecular Formula: C₇H₆D₃NO₂
Molecular Weight: 142.170
Catalog: Signaling Pathways Anti-infection HCV
Create Date: 2021-06-14 03:27:49
Modify Date: 2024-01-09 19:18:04
Deferiprone-d3 is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload[1][2].

Name	Deferiprone-d3
Synonyms	3-Hydroxy-2-methyl-1-(2H3)methyl-4(1H)-pyridinone 4(1H)-Pyridinone, 3-hydroxy-2-methyl-1-(methyl-d3)- DEFERIPRONE-D3

Description	Deferiprone-d3 is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Anti-infection >> HCV Signaling Pathways >> Apoptosis >> Ferroptosis
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584.