911110-38-8

911110-38-8 structure

Name: SB 706504
Chemical Name: SB 706504
CAS Number: 911110-38-8
Molecular Formula: C₂₄H₁₉F₃N₈O
Molecular Weight: 492.456
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2021-05-16 19:32:53
Modify Date: 2024-01-28 13:03:02
SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD)[1].

Name	SB 706504
Synonyms	{2-[N-(2-{[8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}ethyl)carbamimidoyl]hydraziniumylidyne}methanide

Description	SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD)[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
In Vitro	SB 706504 (3 μM, 6 h)可显着降低 IL-1β、IL-6、GM-CSF、TNFα 和 IL-8 mRNA 水平，在 LPS 刺激的单核细胞来源的巨噬细胞（MDM）中[1]。 SB 706504(3 μM, 6 h)可显着降低 COPD 患者肺泡巨噬细胞（AM）中 LPS 诱导的 TNFα 水平，抑制率为 67.4%[1]。
References	[1]. Lauren M. Kent, et al. Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504).