60320-05-0

60320-05-0 structure

Name: (3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid
Chemical Name: Cholic Acid 7-sulfate
CAS Number: 60320-05-0
Molecular Formula: C₂₄H₄₀O₈S
Molecular Weight: 488.635
Create Date: 2021-05-16 16:27:29
Modify Date: 2024-01-29 17:38:32
Cholic acid 7-sulfate (7-Sulfocholic acid), a metabolite of Cholic acid, is a Takeda G-protein receptor 5 (TGR5) agonist. Cholic acid 7-sulfate can increase Tgr5 expression and induce GLP-1 secretion[1].

Name	Cholic Acid 7-sulfate
Synonyms	7-Sulfocholic acid Cholic acid 7-sulfate (3α,5β,7α,12α)-3,12-Dihydroxy-7-(sulfooxy)cholan-24-oic acid (3a,5b,7a,12a)-3,12-Dihydroxy-7-(sulfooxy)-cholan-24-oic acid Cholan-24-oic acid, 3,12-dihydroxy-7-(sulfooxy)-, (3α,5β,7α,12α)-

Description	Cholic acid 7-sulfate (7-Sulfocholic acid), a metabolite of Cholic acid, is a Takeda G-protein receptor 5 (TGR5) agonist. Cholic acid 7-sulfate can increase Tgr5 expression and induce GLP-1 secretion[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPCR19 Research Areas >> Metabolic Disease
Target	TGR[1]
References	[1]. Chaudhari SN, et, al. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nat Chem Biol. 2021 Jan;17(1):20-29.