929978-58-5

929978-58-5 structure

Name: Fasnall
Chemical Name: Fasnall (benzenesulfonate)
CAS Number: 929978-58-5
Molecular Formula: C₁₉H₂₂N₄S
Molecular Weight: 338.47
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-01-09 16:48:12
Modify Date: 2024-01-18 17:47:08
Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities[1].

Name	Fasnall (benzenesulfonate)
Synonyms	Fasnall benzenesulfonate salt 5,6-Dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]thieno[2,3-d]pyrimidin-4-amine benzenesulfonate N-(1-Benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d] pyrimidin-4-amine benzenesulfonate N-(1-Benzyl-3-pyrrolidinyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine benzenesulfonate (1:1) Fasnall (benzenesulfonate) Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-, benzenesulfonate (1:1)

Description	Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)
Target	IC50: 3.71 μM (human purified FASN activity)[1]
References	[1]. Yazan Alwarawrah, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23(6):678-88.