823830-85-9

823830-85-9 structure

Name: M1002
Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide
CAS Number: 823830-85-9
Molecular Formula: C₁₅H₈F₆N₂O₂S
Molecular Weight: 394.292
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2021-01-15 19:47:18
Modify Date: 2024-01-11 12:11:09
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1].

Name	N-[3,5-Bis(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide
Synonyms	1,2-Benzisothiazol-3-amine, N-[3,5-bis(trifluoromethyl)phenyl]-, 1,1-dioxide MFCD05999002 N-[3,5-Bis(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide

Description	M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
In Vitro	M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy[1]. M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors[1]. RT-PCR[1] Cell Line: 786-O cells Concentration: 10 μM Incubation Time: 24 hours Result: Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control. RT-PCR[1] Cell Line: Hep3B cells Concentration: 5 μM Incubation Time: 24 hours Result: Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.
References	[1]. Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.