2254605-76-8

2254605-76-8 structure

Name: MD001
Chemical Name: MD001
CAS Number: 2254605-76-8
Molecular Formula: C₂₅H₁₈O₅
Molecular Weight: 398.407
Create Date: 2021-01-09 18:22:16
Modify Date: 2025-08-25 21:52:43
MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ. It binds to PPARα and PPARγ but does not bind to PPARβ/δ. It increases transcriptional activity of PPARα and PPARγ and glucose consumption. MD001 decreases levels of glucose, insulin, free fatty acids, triglycerides, LDL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice.

Name	MD001
Synonyms	2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl- MD001 5,7-Dihydroxy-8-methyl-4-phenyl-3-[(2E)-3-phenyl-2-propenoyl]-2H-chromen-2-one