1041438-68-9

1041438-68-9 structure

Name: STAT3-IN-8
Chemical Name: Ethyl 1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate
CAS Number: 1041438-68-9
Molecular Formula: C₁₉H₇F₇N₂O₃
Molecular Weight: 444.259
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2021-01-07 23:50:02
Modify Date: 2024-01-11 15:09:19
STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC50 value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer[1].

Name	Ethyl 1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate
Synonyms	Ethyl 1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate 3-Quinolinecarboxylic acid, 1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-, ethyl ester

Description	STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC50 value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
Target	p-STAT3:170 nM (EC50)
In Vitro	STAT3-IN-5 (compound 8; 0-2 μM; 1 h) 抑制 U266 细胞中的 STAT3 磷酸化[1]。 STAT3-IN-5 (0-2 μM; 1 h) 抑制 U266 细胞中细胞因子诱导的 JAK1、JAK2 和 Tyk2 磷酸化[1]。 Western Blot Analysis[1] Cell Line: U266 cells Concentration: 0-2 μM Incubation Time: 1 hours Result: Inhibited cytokine induced phosphorylation of JAK1, JAK2, and Tyk2 (P-JAK1-Y1022/1023, P-JAK2-Y1007/1008, P-Tyk2-Y1054/1055). Western Blot Analysis[1] Cell Line: U266 cells Concentration: 0-2 μM Incubation Time: 1 hours Result: Inhibited STAT3 phosphorylation in a dose-dependent manner.
References	[1]. Xu J, et, al. Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem. 2008 Jul 24;51(14):4115-21.