2375815-63-5
2375815-63-5 structure
- Name: CD73-IN-3
- Chemical Name: 5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione
- CAS Number: 2375815-63-5
- Molecular Formula: C15H18N4O2
- Molecular Weight: 286.33
- Catalog: Research Areas Cancer
- Create Date: 2021-01-08 18:15:20
- Modify Date: 2025-08-27 13:45:55
-
CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research[1].
| Name | 5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione |
|---|
| Description | CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | CD73-IN-3 inhibits CD73 activity in human serum with an EC50 of 0.213 μM. CD73-IN-3 inhibits CD73 activity in human serum by 56.8%, 71.7% and 76.9% at 0.52 μM, 1.56 μM, 4.68 μM,respectively[1]. In Calu6 human cell assay against CD73, the IC50 for CD73-IN-3 against CD73 is 0.0073 uM[1]. |
| References |
[1]. Robert Dean Dally, et al. Cd73 inhibitors. Patent WO2019168744 A1. |
| Molecular Formula | C15H18N4O2 |
|---|---|
| Molecular Weight | 286.33 |
| Exact Mass | 286.14297583 |