484598-35-8

484598-35-8 structure

Name: ProTx I
Chemical Name: ProTx-I
CAS Number: 484598-35-8
Molecular Formula: ₄₈₄₅₉₈-₃₅-₈
Molecular Weight: 3988.00
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2020-08-08 19:47:27
Modify Date: 2024-04-03 18:01:18
ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective CaV3.1 channel blocker with IC50 values of 0.2 μM and 31.8 μM for hCaV3.1 and hCaV3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na+ channels and inhibits KV 2.1 channels[1][2].

Name	ProTx-I

Description	ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective CaV3.1 channel blocker with IC50 values of 0.2 μM and 31.8 μM for hCaV3.1 and hCaV3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na+ channels and inhibits KV 2.1 channels[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.2 μM (hCaV3.1) and 31.8 μM (hCaV3.2)[1] Na+ channels[2] KV 2.1 channels[2]
References	[1]. Tsuyako Ohkubo, et al. Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ Channels Cav3.1 and Cav3.2. J Pharmacol Sci. 2010;112(4):452-8. [2]. Richard E Middleton, et al. Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry. 2002 Dec 17;41(50):14734-47.

Molecular Formula	₄₈₄₅₉₈-₃₅-₈
Molecular Weight	3988.00