945260-14-0
945260-14-0 structure
- Name: (S)-3-Hydroxy Midostaurin
- Chemical Name: (S)-3-Hydroxy Midostaurin
- CAS Number: 945260-14-0
- Molecular Formula: C35H30N4O5
- Molecular Weight: 586.64
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FLT3
- Create Date: 2020-06-04 14:44:35
- Modify Date: 2024-01-11 15:38:36
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(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].
| Name | (S)-3-Hydroxy Midostaurin |
|---|
| Description | (S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1]. |
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| Related Catalog | |
| In Vitro | (S)-3-Hydroxy Midostaurin ((S)-CGP52421; compound 4) has IC50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1]. The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive[1]. |
| References |
| Molecular Formula | C35H30N4O5 |
|---|---|
| Molecular Weight | 586.64 |