942577-31-3
942577-31-3 structure
- Name: NP213
- Chemical Name: NP213
- CAS Number: 942577-31-3
- Molecular Formula: C42H84N28O7
- Molecular Weight: 1093.30
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2020-06-01 12:16:56
- Modify Date: 2024-01-06 10:18:05
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NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections[1][2].
| Name | NP213 |
|---|
| Description | NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections[1][2]. |
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| Related Catalog | |
| Target |
IC50: fungal[1] |
| In Vitro | NP213 (500-1000 μg/mL; 18 hours) increases the number of PI-stained T. rubrum NCPF0118 cells in samples. This results suggests that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization[1]. NP213 is against T. rubrum NCPF0118, shows different MIC values against T. rubrum NCPF0118, and the MICs varies depending on the source of the keratin. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin and Lamb’s wool Keratin, respectively[1]. NP213 (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus spp and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 µg/ml[3]. |
| In Vivo | NP213 (25 mg/kg) is well tolerated in mice. In Murine models of acute disseminated candidiasis, NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h[3]. |
| References |
| Molecular Formula | C42H84N28O7 |
|---|---|
| Molecular Weight | 1093.30 |