1384864-80-5
1384864-80-5 structure
- Name: NCGC00249987
- Chemical Name: NCGC00249987
- CAS Number: 1384864-80-5
- Molecular Formula: C16H11FN4O2S
- Molecular Weight: 342.35
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2020-06-02 04:37:37
- Modify Date: 2024-01-09 18:17:39
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NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells[1].
| Name | NCGC00249987 |
|---|
| Description | NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells[1]. |
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| Related Catalog | |
| Target |
IC50: 3 μM (Eya2 ED) and 6.9 μM (MBP-Eya2 FL)[1] |
| In Vitro | NCGC00249987 inhibits Eya2 ED (C-terminal Eya Domain). NCGC00249987 inhibits full length Eya2 including but not other Eya family members[1]. NCGC00249987 binding leads to a conformational change of the active site that is unfavorable for Mg2+ binding, thereby inhibiting Eya2’s Tyr phosphatase activity[1]. NCGC00249987 (5, 10 μM) treatment effectively suppresses migration, invadopodia formation and invasion in Eya2 WT expressing Calu-6 cells, but not in EV Calu-6 cells. NCGC00249987 does not inhibit cell growth or survival[1]. |
| References |
| Molecular Formula | C16H11FN4O2S |
|---|---|
| Molecular Weight | 342.35 |